Endocrine Abstracts

Background: Thyroid hormones may affect bone calcium metabolism either by a direct action on osteoclasts or by acting on osteoblasts which mediate osteoclastic bone resorption. Hyperthyroidism induces an accelerated bone loss, causing hypercalcemia and may thereby increase the risk of low energy fractures. Increased IL-6 levels and hyperadrenergic state due to thyrotoxicosis, are also implicated in hypercalcemia.Case: A 33 year old who is a known case of...

Introduction: The Sonic hedgehog (Shh) pathway is an evolutionarily conserved signalling pathway, playing an essential role during embryonic development. Murine studies have shown the importance of Shh in the growth of the adrenocortical primordium. Shh expression has previously been described in relatively undifferentiated sub-capsular cells in the developing rodent adrenal, however the organisation of the human foetal adrenal (HFA) is unique. This novel study aimed to descri...

Introduction: Resolution of pituitary tumour without surgical intervention is rare. The mechanism of spontaneous resolution of pituitary adenoma is unclear but may be explained by either pituitary apoplexy or hypophysitis responding to steroids. Bray BP, et al(2021) reported the case of vanishing pituitary mass due pituitary apoplexy. Park SM, et al (2014) reported 22 cases of pituitary mass due hypophysititis which improved mostly with medical therapy.C...